Application Note: WB: 1:500-1:2000. ICC/IF: 1:50-1:200. IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 110
Form: Liquid
Buffer (with preservative): PBS, 150mM NaCl, 50%Glycerol, 0.02% Sodium Azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
Uniprot ID: O75460
Antigen Species: Human
Immunogen: A synthesized peptide derived from human ERN1(Accession O75460), corresponding to amino acid residues around phosphorylated Ser724.
Purification: Purified by affinity chromatography via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Conjugation: Unconjugated
Full Name: endoplasmic reticulum to nucleus signaling 1
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