Irinotecan Hydrochloride Trihydrate, CAS 136572-09-3

Purity: >99%

Concentration: 1000 mg

Molecular Weight: 677.18

CAS Number: 136572-09-3

Activity: Irinotecan hydrochloride trihydrate (CPT 11) a compound within the camptothecin family is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. This compound is a prodrug which needs to be transformed by carboxylesterases to its active metabolite SN-38.

Effect: As a Topo I inhibitor Irinotecan inhibits the religation step of the enzyme's normal action inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan has a therapeutic effect in malignant brain tumors with increased efficacy when combined in neural stem cells therapies.

References: 1. Goto S. et al. 1996. Anticancer Res. 16(5A): 2507-2511. PMID: 8917343 2. Metz MZ. et al. 2013. Stem Cells Transl Med. 2(12): 983-992. PMID: 24167321 3. Hong SH. et al. 2013. Cancer Gene Ther. 20(12): 678-682. PMID: 24310061

Formula: C33H38N4O6.HCl.3H2O

Solubility: DMSO water

Stability and Storage: Stable at -20°C. Keep away from direct sunlight.

• Artikelnummer: CGSSM61-1000
• Hersteller: Cell Guidance Systems
• Hersteller Artikelnummer: SM61-1000
• Verpackungseinheit: 1 g
• Mengeneinheit: STK