Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (aE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-a-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, methyl ester
Purity: ≥95%
Formula Markup: C22H26N2O4
Formula Weight: 382.45292
CAS Number: 51014-29-0
Notes: Isocorynoxeine is an alkaloid that has been found in Uncaria and has diverse biological activities.{57268,61578,61579,61580} It inhibits LPS-induced production of nitric oxide (NO) in primary rat microglia (IC50 = 13.7 µM).{57268} Isocorynoxeine (100 µM) protects against glutamate-induced cytotoxicity in HT22 mouse hippocampal cells.{61578} It induces relaxation of isolated rat arterial rings precontracted with phenylephrine or potassium chloride in a concentration-dependent manner.{61579} Isocorynoxeine (30 mg/kg) reduces head twitch behavior induced by reserpine (Item No. 16474) in mice.{61580}
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