ISRIB (trans-isomer), CAS 1597403-47-8

Product Description: ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM).

Applications: Neuroscience-Neurodegeneration

Formula: C22H24Cl2N2O4

References: [1]Sidrauski C, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498./[2]Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stressgranule assembly. Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033.

CAS Number: 1597403-47-8

Molecular Weight: 451.34

Compound Purity: 98.73

Research Area: Neurological Disease

Solubility: DMSO : 4.55 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Apoptosis;Autophagy;PERK

• Artikelnummer: MEXHY-12495-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-12495-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK