ITF 2357, CAS 732302-99-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-[(hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, monohydrochloride, monohydrate

Purity: ≥98%

Formula Markup: C24H27N3O4 / HCl [H2O]

Formula Weight: 476.0

CAS Number: 732302-99-7

Notes: ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFα, IL-1α, and IL-1β (IC50s = 10-22 nM).{22291} ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F (IC50s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera.{22292}

• Artikelnummer: CAY11045-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11045-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK