Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1H-benzotriazol-1-yl(2,4-dichlorophenyl)-methanone
Purity: ≥95%
Formula Markup: C13H7Cl2N3O
Formula Weight: 292.1
CAS Number: 200626-61-5
Notes: Trichostatin A (TSA; Item No. 89730) is a potent, reversible inhibitor of histone deacetylase (HDAC) that inhibits HDAC1 (IC50 = 70 nM) in Jurkat cells, resulting in cell cycle arrest.{8150} ITSA1 is a cell-permeable benzotriazole amide that blocks TSA action, reducing TSA-induced acetylation of histone and tubulin in A549 cells when given at 50 µM.{30169} At the same concentration, ITSA1 also prevents TSA-mediated cell cycle arrest and apoptosis.{30169} It similarly blocks the action of the HDAC inhibitor SAHA (Item No. 10009929), preventing SAHA-induced hyperacetylation of tubulin in A549 cells.{30169} ITSA1 reduces TSA-regulated transcription in mouse embryonic stem cells and in zebrafish.{30169}
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