Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide
Purity: ≥95%
Formula Markup: C23H20N4O3S3
Formula Weight: 496.6
CAS Number: 686772-17-8
Notes: IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM.{17505} IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.{23268}
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