JI051, CAS 2234281-75-3

Product Description: JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].

Applications: Cancer-programmed cell death

Formula: C22H24N2O3

References: [1]Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.

CAS Number: 2234281-75-3

Molecular Weight: 364.44

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Notch

• Artikelnummer: MEXHY-117113-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-117113-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK