JMJD3/HDAC-IN-1, CAS 2883046-06-6

Product Description: JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].

Applications: Cancer-programmed cell death

Formula: C21H30N6O2

References: [1]Li A, et al. Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors. Bioorg Med Chem Lett. 2023 Oct 1;94:129466.. .

CAS Number: 2883046-06-6

Molecular Weight: 398.50

Research Area: cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;HDAC;Histone Demethylase

• Artikelnummer: MEXHY-156094-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-156094-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK