JNJ-47117096 hydrochloride, CAS 1610536-69-0

Product Description: JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.

Applications: Cancer-Kinase/protease

Formula: C21H23ClN4O2

References: [1]Johnson CN, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6(1):25-30./[2]Beke L, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015 Oct 2;35(6). pii: e00267.

CAS Number: 1610536-69-0

Molecular Weight: 398.89

Compound Purity: 99.68

Research Area: Cancer

Solubility: DMSO : ≥ 250 mg/mL/H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)

Target: FLT3;MELK

• Artikelnummer: MEXHY-12420-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-12420-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK