JNJ-61432059, CAS 2035814-50-5

Product Description: JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

Applications: Neuroscience-Neuromodulation

Formula: C25H22FN5O2

References: [1]Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018 Dec 26;10(3):267-272.

CAS Number: 2035814-50-5

Molecular Weight: 443.47

Compound Purity: 99.18

Research Area: Neurological Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: iGluR

• Artikelnummer: MEXHY-111751-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-111751-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK