Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone
Purity: ≥98%
Formula Markup: C14H16ClN3O
Formula Weight: 277.8
CAS Number: 459168-41-3
Notes: JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors.{18909} Its Ki values for the histamine H1-3 receptors exceed 1 μM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters.{18909} JNJ-777120 inhibits mast cell chemotaxis induced by 10 μM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.).{18909} It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation.{18910, 18911}
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