Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
Purity: ≥98%
Formula Markup: C22H23NO2
Formula Weight: 333.4
CAS Number: 1354359-53-7
Notes: The transmembrane enzyme KIAA1363 (also known as AADACL1) controls the production of the monoalkylglycerol ether (MAGE) class of neutral ether lipids (NELs) in cancer cells.{14603} Hyperactivity of this 2-acetyl MAGE hydrolase is associated with tumor cell migration, invasion, survival, and growth.{19445} JW 480 acts as a potent, selective inhibitor of KIAA1361 (IC50s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes), showing little cross reactivity with hormone-sensitive lipase, acetylcholinesterase, or other serine hydrolases.{19445} JW 480 is active in vivo, reducing PC3 tumor xenograft growth in immune-deficient SCID mice at an oral dose of 80 mg/kg.{19445}
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