JY-2, CAS 339103-05-8

Product Description: JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C13H7Cl2N3O

References: [1]Choi HE, et al. Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model. Eur J Pharmacol. 2021 May 15;899:174011.

CAS Number: 339103-05-8

Molecular Weight: 292.12

Compound Purity: 99.75

Research Area: Metabolic Disease

Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

Target: FOXO

• Artikelnummer: MEXHY-153347-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-153347-10.1
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK