Product Description: K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.
Applications: COVID-19-immunoregulation
Formula: C23H32Cl2N6OS3
References: [1]Ikenoya M, et al. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7./[2]Shibuya Y, et al. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging. 2015 Jul;36(7):2248-2259.
CAS Number: 217094-32-1
Molecular Weight: 575.64
Compound Purity: 99.42
Research Area: Cardiovascular Disease
Solubility: DMSO : 62.5 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: Acyltransferase
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