Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[2-(1H-benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide, dihydrochloride
Purity: ≥98%
Formula Markup: C23H30N6OS3 / 2HCl
Formula Weight: 575.6
CAS Number: 217094-32-1
Notes: K-604 is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1; IC50 = 0.45 µM).{51883} It is selective for ACAT-1 over ACAT-2 (IC50 = 102.85 µM). K-604 reduces foaming of J774 macrophages (IC50 = 0.026 µM) and reduces cholesterol esterification in monocyte-derived macrophages (IC50 = 0.068 µM).{51883,51884} It decreases lipid-accumulation areas in the aortic arch in atherosclerosis-susceptible Bio F1B hamsters fed a high-fat and high-cholesterol diet when administered at a dose of 10 mg/kg and reduces plasma total cholesterol levels in the same model at 10 and 30 mg/kg.{51883} K-604 also increases the LC3-II-to-LC3-I ratio, a marker of autophagosome formation, in Neuro2a (N2a) mouse neuroblastoma cells when used at concentrations of 0.1 and 1 µM.{51885} It decreases wild-type and mutant P301L-tau levels in N2a cells overexpressing these proteins but does not affect endogenous tau levels. Intranasal administration of K-604 (105 µg/animal) reduces the level of brain cholesteryl esters in mice.{51885}
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