Product Description: K-Ras-IN-1 is a small molecule K-Ras inhibitor. K-Ras-IN-1 binds to K-Ras (WT), K-Ras (G12D), K-Ras (G12V), and H-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. K-Ras-IN-1 is promising for research of pancreatic, colon and lung cancer[1][2].
Applications: Cancer-Kinase/protease
Formula: C11H13NOS
References: [1]Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538./[2]Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3.
CAS Number: 84783-01-7
Molecular Weight: 207.29
Compound Purity: 98.00
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Ras
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