Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-urea
Purity: ≥98%
Formula Markup: C24H26F3N7O2
Formula Weight: 501.5
CAS Number: 853299-07-7
Notes: K03861 is an inhibitor of cyclin-dependent kinase 2 (Cdk2).{66869} It binds to wild-type Cdk2, Cdk2C118L, Cdk2A144C, and Cdk2C118L/A144C (Kds = 50, 18.6, 15.4, and 9.7 nM, respectively). K03861 selectively inhibits the proliferation of IL-3-stimulated Ba/F3 cells expressing an FMS-related tyrosine kinase 3 bearing internal-tandem duplication (FLT3-ITD) over wild-type Ba/F3 cells (IC50s = ~0.001 and > 0.1 µM, respectively).{66870} It inhibits human cytomegalovirus replication in primary human monocyte-derived macrophages (IC50 = 1.028 µM).{66871} K03861 (10 µM) inhibits spindle organization and chromosome alignment in meiosis I and prevents egg activation in isolated mouse oocytes.{66872}
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