K145 (hydrochloride), CAS 1449240-68-9

Product Description: K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity[1].

Applications: Cancer-Kinase/protease

Formula: C18H25ClN2O3S

Citations: Biochem Biophys Res Commun. 2021 Sep 28;580:1-6./Am J Cancer Res. 2019 Mar 1;9(3):546-561./Biochem Biophys Res Commun. 2017 Nov 4;493(1):286-290. /Channels. 2020 Dec;14(1):216-230./Exp Mol Pathol. 2016 Feb;100(1):51-8. /Sci China Life Sci. 2021 May 27;1-21.

References: [1]Liu K, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013;8(2):e56471.

CAS Number: 1449240-68-9

Molecular Weight: 384.92

Compound Purity: 99.88

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Apoptosis;SphK

• Artikelnummer: MEXHY-15779A-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15779A-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK