Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[([1,1’-biphenyl]-4-ylamino)carbonyl]-benzoic acid
Purity: ≥98%
Formula Markup: C20H15NO3
Formula Weight: 317.3
CAS Number: 4727-31-5
Notes: Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM.{20986} Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.{20986}
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