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Encompassing Amino Acids: 470-820
Application: Useful for SDS-PAGE.
Background: KAT6A (K (lysine) acetyltransferase 6A), also known as MYST3 or MOZ, is a histone acetyltransferase (HAT) that acetylates lysine residues in histone H3 and histone H4 (in vitro). KAT6A is a component of the MOZ (monocytic leukemic zinc finger)/MORF complex with histone H3 acetyltransferase activity. This protein may act as a transcriptional coactivator for RUNX1 (runt-related transcription factor 1) and RUNX2. It also functions to acetylate p53 (encoded by tumor suppressor gene TP53) and controls its transcriptional activity. Dysregulation of KAT6A is associated with acute myeloid leukemia (AML) as this protein plays crucial roles in hematopoietic stem cells, tumor progression, and developmental delays. KAT6 mutations also result in KAT6A syndrome, also known as ARTHS (Arboleda-Tham Syndrome), a disorder that affects multiple organs. Inhibition of KAT6A with the inhibitor WM-8014 resulted in cellular senescence in a model of hepatocellular carcinoma (HCC). These results open new insights and therapeutic approaches in KAT6A related disorders.
Description: Recombinant human KAT6A (K (lysine) acetyltransferase 6A), also known as MOZ, encompassing amino acids 470-820. This construct contains a N-terminal FLAG-tag. The recombinant protein was affinity purified.
Format: Aqueous buffer solution
Formulation: 40mM Tris, pH 8, 110 mM NaCl, 2.2 mM KCI, 80 ng/µl FLAG peptide, and 20% glycerol.
Genbank: NP_006757.2
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: FLAG
Target: KAT6A
Uniprot: Q92794
Warnings: Avoid freeze/thaw cycles. Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.
Biosafety Level: Not applicable (BSL-1)
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