KP372-1, CAS 1374996-60-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6H-indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one, compd. with 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1)

Purity: ≥95% (sum of isomers)

Formula Markup: C10H4N6O / C10H4N6O

Formula Weight: 224.2

CAS Number: 1374996-60-7

Notes: KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K.{26547} In acute myelogenous leukemia cells, KP372-1 is reported to inhibit the kinase activity of Akt, PDK1, and FLT3, decreasing the colony-forming ability of these cells with an IC50 value less than 200 nM.{26547}

• Artikelnummer: CAY17808-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17808-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK