KRN 633, CAS 286370-15-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-urea

Purity: ≥95%

Formula Markup: C20H21ClN4O4

Formula Weight: 416.9

CAS Number: 286370-15-8

Notes: KRN 633 is an ATP-competitive inhibitor of VEGFR kinase activity (IC50s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively).{23658} At higher concentrations KRN 633 inhibits PDGFR-α and c-KIT with IC50 values of 0.97 and 4.3 μM, respectively, and is inactive towards a panel of 17 additional kinases.{23658} KRN 633 suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.{24366}

• Artikelnummer: CAY14871-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14871-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK