Product Description: KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC50=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages[1].
Applications: Metabolism-sugar/lipid metabolism
Formula: C27H26N4O
References: [1]Ku-Lung Hsu, et al. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol. 2012 Dec;8(12):999-1007.
CAS Number: 1402612-55-8
Molecular Weight: 422.52
Compound Purity: 99.82
Research Area: Metabolic Disease; Inflammation/Immunology
Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Target: DAGL;MAGL
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