Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol
Purity: ≥98%
Formula Markup: C25H31N5O4
Formula Weight: 465.5
CAS Number: 938440-64-3
Notes: The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival.{16931} Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 10 nM).{17538} It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks.{17538} Ku-0063794 inhibits cell growth by inducing G1-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).{17538,23552,23551}
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