KU-0063794, CAS 938440-64-3

Product Description: KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC50s of 10 nM.

Applications: Cancer-Kinase/protease

Formula: C25H31N5O4

References: [1]Garcia-Martinez et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. (2009)421 29./[2]Collak FK, et al. Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.J Biol Chem. 2012 Jul 6;287(28):23698-709. E/[3]Haagensen EJ, et al. The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition. Br J Cancer. 2012 Apr 10;106(8):1386-94.

CAS Number: 938440-64-3

Molecular Weight: 465.54

Compound Purity: 99.55

Research Area: Cancer

Solubility: DMSO : 16.67 mg/mL (ultrasonic)

Target: mTOR

• Artikelnummer: MEXHY-50710-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-50710-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK