Product Description: L-168049 is a potent, selective, orally active and non-competitive glucagon receptor antagonist with IC50s of 3.7 nM, 63 nM, and 60 nM for human, murine, and canine glucagon receptors, respectively[1][2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C24H20BrClN2O
References: [1]S E de Laszlo, et al. Potent, orally absorbed glucagon receptor antagonists. Bioorg Med Chem Lett. 1999 Mar 8;9(5):641-6./[2]M A Cascieri, et al. Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor. J Biol Chem. 1999 Mar 26;274(13):8694-7./[3]Elodie Mutel, et al. Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon. Diabetes. 2011 Dec;60(12):3121-31.
CAS Number: 191034-25-0
Molecular Weight: 467.79
Compound Purity: 99.93
Research Area: Metabolic Disease
Solubility: DMSO : ≥ 50 mg/mL
Target: GCGR
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