Shelf life (days): 1460.0
Formulation: A solid
Formal Name: S-(methyl-d3)-L-homocysteine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C5H8D3NO2S
Formula Weight: 152.23056
CAS Number: 13010-53-2
Notes: L-Methionine-d3 is intended for use as an internal standard for the quantification of L-methionine by GC- or LC-MS. L-Methionine is an essential amino acid.{58764,58765} It is catabolized by methionine adenosyltransferase 2A (MAT2A), yielding the universal methyl donor S-(5’-adenosyl-L-methionine (SAM; Item Nos. 16376 / 17595).{58765} L-methionine has roles in purine and pyrimidine synthesis, polyamine synthesis, and glutathione production, as well as in various metabolic diseases and aging. Dietary methionine restriction (MR) prevents accelerated aging in a mouse model of progeria and increases the lifespan of yeast, Drosophila, C. elegans, mice, and rats.{58764,58765} MR also improves insulin sensitivity and reduces adiposity in mice, as well as inhibits the growth and proliferation of several cancer cell lines.
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