Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-valine-2,3,4,4,4,4',4',4'-d8, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, monohydrochloride
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C13H12D8N6O4 / HCl
Formula Weight: 368.84506
CAS Number: 1279033-32-7
Notes: L-Valacyclovir-d8 is intended for use as an internal standard for the quantification of L-valacyclovir (Item No. 23801) by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir (Item No. 14160). L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50 = 0.84 µM in Vero cells).{41278} It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.{41279} Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
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