Laquinimod, CAS 248281-84-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide

Purity: ≥98%

Formula Markup: C19H17ClN2O3

Formula Weight: 356.80266

CAS Number: 248281-84-7

Notes: Laquinimod is an orally bioavailable immunomodulator.{40911} It induces expression of genes related to antigen presentation and inflammatory pathways in human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 0.1 μM.{40912} In a mouse model of acute autoimmune encephalomyelitis (aEAE), laquinimod (5 mg/kg per day) decreases the severity of symptoms by 91.4%, and it decreases the number of relapses in a mouse model of chronic EAE (crEAE).{40911} It decreases T cell and macrophage density and demyelination in the spinal cord of EAE mice compared to non-treated controls when administered at a dose of 5 mg/kg per day.{40913} Laquinimod (12.5 and 25 mg/kg per day) decreases inflammatory lesions and demyelination in the sciatic nerve in a rat model of experimental autoimmune neuritis (EAN).{40914} Laquinimod (25 mg/kg per day) activates gene expression in the aryl hydrocarbon receptor (AhR) pathway in splenocytes from EAE mice with no effect in AhR knockout mice.{40915}

• Artikelnummer: CAY24187-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24187-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK