LATS2, GST-Tag Recombinant

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Encompassing Amino Acids: 488-1088

Applications: Kinase Assay, Western blot

Background: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction (1). LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity (2).

Description: Human LATS2 protein with N-terminal GST-Tag, GenBank Accession No. NM_014572, a.a 480-1088, expressed in an Sf9 expression system. MW = 110 kDa.

Format: Aqueous buffer solution

Formulation: 50 mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Genbank: NM_014572

Storage Stability: Store product at -80°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Tags: GST tag

Uniprot: Q9NRM7

Biosafety Level: Not applicable (BSL-1)

References: 1. Aylon, Y. et.al: A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20: 2687-2700, 2006. 2. McPherson, J. P. et.al: Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 23: 3677-3688, 2004.

• Artikelnummer: BPS79042
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79042
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK