LDE225 (phosphate), CAS 1218778-77-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: rel-N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide, diphosphate

Purity: ≥98%

Formula Markup: C26H26F3N3O3 / 2H3PO4

Formula Weight: 681.5

CAS Number: 1218778-77-8

Notes: LDE225 is a smoothened (Smo) antagonist (IC50s = 1.3 and 2.5 nM for mouse and human Smo, respectively).{27243} In vivo, LDE225 (20 mg/kg per day) inhibits Gli1 mRNA expression and prevents tumor growth in an orthotopic Ptch+/- p53-/- medulloblastoma mouse allograft model. Formulations containing LDE225 have been used in the treatment of locally advanced basal cell carcinomas.

• Artikelnummer: CAY16263-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16263-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK