LDN-193189 2HCl, CAS 1435934-00-1

Description: LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively. LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors ALK2 and ALK3 in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively, and was 200-fold more selective for BMP than for TGF-β.

CAS Number: 1435934-00-1

Formula: C25H24Cl2N6

Molecular Weight: 479,4

References: Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification [published correction appears in Nat Med. Nat Med. 2008;14(12):1363-1369.

• Artikelnummer: TGMT35348-1mL
• Hersteller: TargetMol Chemicals
• Hersteller Artikelnummer: T35348-1mL
• Verpackungseinheit: 1 mL
• Mengeneinheit: STK