Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-methyl-N-(4-(trifluoromethyl)phenyl-2,3,5,6-d4)isoxazole-4-carboxamide
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C12H5D4F3N2O2
Formula Weight: 274.231589
CAS Number: 1189987-23-2
Notes: Leflunomide-d4 is intended for use as an internal standard for the quantification of leflunomide (Item No. 14860) by GC- or LC-MS. Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Item No. 14404), a dihydroorotate dehydrogenase inhibitor.{22723} Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of 25 and 100 µM, respectively, for naïve and memory CD4+ T cells.{46073} It also reduces the production of Th1 effector cells and increases differentiation of Th2 cells in vitro and in splenocytes isolated from KLH-immunized mice. Leflunomide (35 mg/kg per day) reduces and prevents inflammation in a proteoglycan-induced mouse model of rheumatoid arthritis.{46074} Formulations containing leflunomide have been used in the treatment of active rheumatoid arthritis.
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