Shelf life (days): 365.0
Formulation: A solution in ethanol
Formal Name: 5S,12R-dihydroxy-6Z,8E,10E,14Z,17Z-eicosapentaenoic acid
Purity: ≥98%
Formula Markup: C20H30O4
Formula Weight: 334.5
CAS Number: 80445-66-5
Notes: Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities.{36392,36393,551,2238,330} It is a metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110 / 90110.1 / 21908) formed through the 5-lipoxygenase (5-LO) pathway.{719} LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner.{36392} In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells.{36393} LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4 (Item No. 20110).{551,2238,330}
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