Shelf life (days): 365.0
Formulation: A solution in ethanol
Formal Name: S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl-14,14,15,15,15-d5]-L-cysteinyl-glycine
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C25H35D5N2O6S
Formula Weight: 501.7
CAS Number: 1240398-17-7
Notes: Leukotriene D4-d5 (LTD4-d5) is intended for use as an internal standard for the quantification of LTD4 (Item No. 20310) by GC- or LC-MS. LTD4 is an active metabolite of LTC4 (Item No. 20210) and a constituent of slow-reacting substance of anaphylaxis (SRS-A).{541,589} It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals.{396} In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal.{4157} It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.
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