Levosimendan, CAS 141505-33-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-[2-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-propanedinitrile

Purity: ≥98%

Formula Markup: C14H12N6O

Formula Weight: 280.3

CAS Number: 141505-33-1

Notes: Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes.{26307,26308} It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 µM, respectively.{26309}

• Artikelnummer: CAY16128-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16128-250
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK