Conjugation: HRP: Horseradish Peroxidase
Description of Target: This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LIG1
Key Reference: Liang,L., (2008) Nucleic Acids Res. 36 (10), 3297-3310
Molecular Weight: 102kDa
Peptide Sequence: Synthetic peptide located within the following region:
ALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDRProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: DNA ligase 1
Protein Size: 919
Purification: Affinity Purified
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