Shelf life (days): 1460.0
Formulation: A solution in methyl acetate
Formal Name: ditetradecyl 4,8,17-tris(3-oxo-3-(tetradecyloxy)propyl)-4,8,13,17-tetraazaicosanedioate
Purity: ≥98%
Formula Markup: C95H186N4O10
Formula Weight: 1544.5143
Notes: An ionizable cationic lipid (pKa = ~6.8); has been used in the generation of LNPs for siRNA delivery in vitro and in vivo; lipid 114-containing LNPs accumulate in the liver and, to a lesser extent, the kidneys in mice; LNPs containing lipid 114 and encapsulating IL-1β-targeting siRNA reduce IL1B expression in activated RAW 264.7 macrophages and primary mouse macrophages in a concentration-dependent manner; lipid 114-containing LNPs encapsulating Il-1β-targeted siRNA reduce hepatic and renal expression of Il1b, as well as decrease hepatic inflammation and damage, in a mouse model of LPS- and D-GalN-induced acute liver failure
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