Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (1S,4aS,6S,7R,7aS)-1-(ß-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-cyclopenta[c]pyran-4-carboxylic acid
Purity: ≥98%
Formula Markup: C16H24O10
Formula Weight: 376.35576
CAS Number: 22255-40-9
Notes: Loganic acid is an iridoid glycoside that has been found in C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties.{46430,46431,46432,46433} Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells.{46431} It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml.{46432} Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet.{46433} It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model.
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