Product Description: Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C10H6Cl3N3
References: [1]Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73./[2]Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60./[3]Green AR, et al. A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Neuropharmacology. 1996;35(9-10):1243-50.
CAS Number: 117857-45-1
Molecular Weight: 274.53
Compound Purity: 99.68
Research Area: Neurological Disease
Solubility: DMSO : 110 mg/mL (ultrasonic)
Target: GABA Receptor
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