Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-[[7-[(1-aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-1-naphthalenecarboxamide
Purity: ≥98%
Formula Markup: C26H25N3O4
Formula Weight: 443.5
CAS Number: 1058137-23-7
Notes: A dual inhibitor of VEGFR and FGFR; inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50s = 7, 25, and 10 nM, respectively) and FGFR1 and FGFR2 (IC50s = 17.5 and 82.5 nM, respectively); selective for VEGFR1-3 and FGFR1-2 over FGFR3 and FGFR4 (IC50s = 237.5 and >1,000 nM, respectively), as well c-Kit, PDGFRα, and PDGFRβ (IC50s = 456, 175, and 525 nM, respectively), but does inhibit FMS (IC50 = 5 nM); inhibits VEGF- or bFGF-induced HUVEC proliferation (IC50s = 40 and 50 nM, respectively) but inhibits the proliferation of A2780, A498, and SN12KI cancer cells only at higher concentrations (IC50s = 27.7, 19.6, and 12.79 µM, respectively); reduces tumor growth in various mouse xenograft models in a dose-dependent manner; completely inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice at 20 mg/kg
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