Product Description: Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
Applications: Neuroscience-Neuromodulation
Formula: C28H37ClN4O2S
Citations: ACS Chem Neurosci. 2020 Jan 15;11(2):173-183./Marmara Pharm J. 2017;21 (4): 931-937./Antibiotics (Basel). 2024 Mar 28, 13(4), 308./bioRxiv. 2024 Jan 14./J Med Chem. 2024 Apr 25;67(8):6144-6188./J Ocul Pharmacol Ther. 2024 Aug 29./Marmara Pharm J. 2017;21 (4): 931-937./Marmara Pharm J. 2017;21 (4): 931-937./Nature. 2023 Dec;624(7992):672-681.
References: [1]Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81./[2]Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.
CAS Number: 367514-88-3
Molecular Weight: 529.14
Compound Purity: 99.96
Research Area: Neurological Disease
Solubility: DMSO : 6.67 mg/mL (ultrasonic;warming;adjust pH to 3 with HCl;heat to 80°C)/Ethanol : 2 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C)
Target: 5-HT Receptor;Dopamine Receptor
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