Product Description: LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression.
Applications: Cancer-programmed cell death
Formula: C26H29NO5
References: [1]Naik R, et al. Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors. J Med Chem. 2014 Nov 26;57(22):9522-38./[2]Lee K, et al. LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. Biochem Pharmacol. 2010 Oct 1;80(7):982-9./[3]Song JG, et al. Discovery of LW6 as a new potent inhibitor of breast cancer resistance protein./[4]Sato M, et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep. 2015 Sep;12(3):3462-8.
CAS Number: 934593-90-5
Molecular Weight: 435.51
Compound Purity: 98.38
Research Area: Cancer
Solubility: DMF : 17.24 mg/mL (ultrasonic)/DMSO : 25 mg/mL (ultrasonic)
Target: Apoptosis;HIF/HIF Prolyl-Hydroxylase
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