LY315920, CAS 172732-68-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-acetic acid

Purity: ≥95%

Formula Markup: C21H20N2O5

Formula Weight: 380.4

CAS Number: 172732-68-2

Notes: LY315920 is an inhibitor of human group IIA (hGIIA) secretory phospholipase A2 (sPLA2; IC50 = 9 nM).{3601} It also potently inhibits human GIIE and GX isoforms, as well as the corresponding mouse isoforms, but poorly inhibits other PLA2 enzymes.{3601,30706,30705,12332} LY315920 inhibits sPLA2-induced release of thromboxane A2 from isolated guinea pig lung bronchoalveolar lavage cells (IC50 = 0.79 µM).{30706} Intravenous or oral administration of LY315920 to transgenic mice expressing human sPLA2 inhibits serum sPLA2 activity in a dose-related manner over four hours.{30706}

• Artikelnummer: CAY18267-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18267-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK