LYNB, GST-tag Recombinant

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Encompassing Amino Acids: full length

Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 

Background: LYN is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck, v-yes, v-fgr and v-src and is expressed in a variety of tissues (1). LYN is expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that LYN is physically associated with membrane-bound IgM, and participates in antigen-mediated signal transduction (2). Crosslinking of membrane-bound IgM with antibody induces rapid increase in activities of LYN and LYN-associated phosphatidylinositol 3-kinase.

Description: Recombinant full-length human LYN B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is BC059394.

Format: Aqueous buffer solution

Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

Genbank: BC059394

Host Cell Line: Sf9 cells

Storage Stability: At least 6 months at -80°C.

Tags: N-terminal GST-tag

Uniprot: P07948

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Yamanashi, Y. et al. Mol Cell Biol. 1987 Jan;7(1):237-43.
2. Yamanashi, Y. et al. Science. 1991 Jan 11;251(4990):192-4.

• Artikelnummer: BPS40472
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 40472
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK
• Wirt: Insect