Product Description: Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.
Applications: Cancer-programmed cell death
Formula: C23H26Cl5N5
References: [1]McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8.
CAS Number: 1391426-24-6
Molecular Weight: 549.75
Compound Purity: 99.89
Research Area: Cancer
Solubility: DMSO : 5.88 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 6.4 mg/mL (ultrasonic)
Target: Autophagy