Product Description: MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals[1].
Applications: Cancer-programmed cell death
Formula: C19H17Cl3N4O3
References: [1]Fontan L, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24.
CAS Number: 1047953-91-2
Molecular Weight: 455.72
Compound Purity: 99.95
Research Area: Cancer
Solubility: DMSO : ≥ 46 mg/mL
Target: MALT1