Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-[(2,3-dimethylphenyl)amino]-benzoic-2,3,4,5-d4 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C15H11D4NO2
Formula Weight: 245.30938
CAS Number: 1216745-79-7
Notes: Mefenamic acid-d4 is intended for use as an internal standard for the quantification of mefenamic acid (Item No. 23650) by GC- or LC-MS. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
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