Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-hydroxy-2-(methyl-d3)-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C14H10D3N3O4S2
Formula Weight: 354.4
CAS Number: 942047-63-4
Notes: Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam (Item No. 14906) by GC- or LC-MS. Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.
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